Method 1: Stop Magnifier Loading Up When Windows 10 Starts In this tutorial we’ll show you 3 ways to turn off or disable Magnifier permanently in Windows 10. When you press the ( Win & +, Win & –) keyboard shortcuts, it will open the Magnifier immediately and you then have to press the Win & ESC keys to close it. Accidentally activate the Magnifier that disrupts your work? Look for a way to prevent the Magnifier from starting up automatically at every startup?